Start with the purpose.

What is the study trying to learn?Ask why the research is being conducted and what is already known about the approach.
Why might I be eligible?Ask which criteria apply and whether additional screening is required.
What are my alternatives?Discuss other research opportunities and non-research care options with an appropriate healthcare professional.

Understand the commitment.

What will happen at each visit?Ask about examinations, samples, questionnaires, treatments, imaging, and remote activities.
How much time is involved?Clarify the number, location, and length of visits as well as the overall study duration.
What happens between visits?Ask about diaries, devices, medication schedules, phone calls, and whom to contact.

Discuss safety and uncertainty.

Ask which risks or discomforts are known, which remain uncertain, how side effects are monitored, and what care is available if a study-related problem occurs. Find out whether an investigational treatment could interact with current medications or health conditions.

Clarify costs, payment, and logistics.

Ask which services are paid for by the study, what could be billed to you or your insurance, and whether compensation or reimbursement is available for time, travel, parking, meals, or lodging. Also ask what happens if you miss a visit or your circumstances change.

Ask how information and samples are handled.

Learn who may access research records, how information is coded or protected, whether samples may be stored for future research, and what choices you have. The consent information should describe relevant privacy practices.

Before you say yes

Consider whether the study’s purpose, schedule, procedures, uncertainty, and practical demands fit your priorities. Joining may or may not provide direct medical benefit. You may decline, request more time, or ask additional questions without pressure.